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Total 167 results found since Jan 2013.

Monitoring, prophylaxis, and treatment of infections in patients with MM receiving bispecific antibody therapy: consensus recommendations from an expert panel
Blood Cancer J. 2023 Aug 1;13(1):116. doi: 10.1038/s41408-023-00879-7.ABSTRACTBispecific antibodies (BsAbs) are emerging as an important novel class of immunotherapeutic agents for the treatment of multiple myeloma (MM), and are set to be more widely used in clinical practice. However, this new class of therapies is associated with a distinct adverse event (AE) profile that includes cytokine release syndrome and immune effector cell-associated neurotoxicity syndrome, as well as AEs leading to increased infection risk such as cytopenias and hypogammaglobulinemia, and infections themselves. As preliminary data with this clas...
Source: Herpes - August 1, 2023 Category: Infectious Diseases Authors: Noopur Raje Kenneth Anderson Hermann Einsele Yvonne Efebera Francesca Gay Sarah P Hammond Alexander M Lesokhin Sagar Lonial Heinz Ludwig Philippe Moreau Krina Patel Karthik Ramasamy Maria-Victoria Mateos Source Type: research

Preventive behaviors and behavioral risk factors among gynecologic cancer survivors: Results from the 2020 Behavioral Risk Factor Surveillance System Survey
CONCLUSION: Smoking prevalence among gynecologic cancer survivors is alarmingly high. Intervention studies are needed to identify effective ways to assist gynecologic cancer survivors to quit smoking and refrain from hazardous alcohol consumption. In addition, women with gynecologic malignancies should made aware of the importance of physical activity.PMID:37387412 | DOI:10.1002/cam4.6134
Source: Cancer Control - June 30, 2023 Category: Cancer & Oncology Authors: Steven S Coughlin Biplab Datta Justin Xavier Moore Marlo M Vernon Martha S Tingen Source Type: research

Thymosin alpha 1 - Reimagine its broader applications in the immuno-oncology era
Int Immunopharmacol. 2023 Mar 3;117:109952. doi: 10.1016/j.intimp.2023.109952. Online ahead of print.ABSTRACTThymosin alpha 1 (Tα1) is a highly conserved 28 amino-acid peptide naturally occurring in the thymus and plays critical roles in T cell maturity and differentiation. Its synthetic form, thymalfasin, has been approved by various regulatory agencies in the treatment of hepatitis B viral infection and as an enhancer of vaccine response in immune-compromised populations. In China, it has also widely utilized in patients with cancer and severe infections, as well as the emergency use during (Severe Acute Respiratory Syn...
Source: International Immunopharmacology - March 5, 2023 Category: Allergy & Immunology Authors: Li Mao Source Type: research

Impact of pharmacist-led educational intervention on pneumococcal vaccination rates in cancer patients: a randomized controlled study
CONCLUSIONS: The pneumococcal vaccination rate in cancer patients has increased significantly by the education provided by a clinical pharmacist in hospital settings.PMID:36856870 | DOI:10.1007/s00520-023-07652-3
Source: Cancer Control - March 1, 2023 Category: Cancer & Oncology Authors: Nesligul Ozdemir Burak Y Aktas Ahmet Gulmez Ahmet C Inkaya Aygin Bayraktar-Ekincioglu Saadettin Kilickap Serhat Unal Source Type: research

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Infant rhesus macaques immunized against SARS-CoV-2 are protected against heterologous virus challenge one year later
Sci Transl Med. 2022 Dec 1:eadd6383. doi: 10.1126/scitranslmed.add6383. Online ahead of print.ABSTRACTThe U.S. Food and Drug Administration only gave emergency-use-authorization of the BNT162b2 and the mRNA-1273 SARS-CoV-2 vaccines for infants 6 months and older in June 2022. Yet, questions regarding the durability of vaccine efficacy, especially against emerging variants, in this age group remain. We demonstrated previously that a two-dose regimen of stabilized prefusion Washington SARS-CoV-2 S-2P spike (S) protein encoded by mRNA encapsulated in lipid nanoparticles (mRNA-LNP) or purified S-2P mixed with 3 M-052, a synthe...
Source: Cancer Control - December 1, 2022 Category: Cancer & Oncology Authors: Emma C Milligan Katherine Olstad Caitlin A Williams Michael Mallory Patricio Cano Kaitlyn A Cross Jennifer E Munt Carolina Garrido Lisa Lindesmith Jennifer Watanabe Jodie L Usachenko Lincoln Hopkins Ramya Immareddy Yashavanth Shaan Lakshmanappa Sonny R El Source Type: research

Mechanisms and challenges of nanocarriers as non-viral vectors of therapeutic genes for enhanced pulmonary delivery
J Control Release. 2022 Nov 10:S0168-3659(22)00739-8. doi: 10.1016/j.jconrel.2022.10.061. Online ahead of print.ABSTRACTWith the rapid development of biopharmaceuticals and the outbreak of COVID-19, the world has ushered in a frenzy to develop gene therapy. Therefore, therapeutic genes have received enormous attention. However, due to the extreme instability and low intracellular gene expression of naked genes, specific vectors are required. Viral vectors are widely used attributed to their high transfection efficiency. However, due to the safety concerns of viral vectors, nanotechnology-based non-viral vectors have attrac...
Source: Cancer Control - November 13, 2022 Category: Cancer & Oncology Authors: Hezhi Wang Lu Qin Xin Zhang Jian Guan Shirui Mao Source Type: research

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The COVID-19 pandemic and disruptions to essential health services in Kenya: a retrospective time-series analysis
Lancet Glob Health. 2022 Sep;10(9):e1257-e1267. doi: 10.1016/S2214-109X(22)00285-6.ABSTRACTBACKGROUND: Public health emergencies can disrupt the provision of and access to essential health-care services, exacerbating health crises. We aimed to assess the effect of the COVID-19 pandemic on essential health-care services in Kenya.METHODS: Using county-level data routinely collected from the health information system from health facilities across the country, we used a robust mixed-effect model to examine changes in 17 indicators of essential health services across four periods: the pre-pandemic period (from January, 2018 to ...
Source: Cancer Control - August 12, 2022 Category: Cancer & Oncology Authors: Helen Kiarie Marleen Temmerman Mutono Nyamai Nzisa Liku Wangari Thuo Violet Oramisi Lilly Nyaga Janette Karimi Phidelis Wamalwa Gladwell Gatheca Valerian Mwenda Loice Achieng Ombajo S M Thumbi Essential Health Services Data Monitoring and Evaluation sub-w Source Type: research

The effect of vaccination against COVID-19 in cancer patients: final results of the COICA trial
Conclusions Vaccination consistently improved all COVID-19 outcomes. No deaths was recorded among vaccinated patients. Additional research is especially warranted to establish optimal timing and patient selection for administration of the fourth vaccination dose.PMID:35817009 | DOI:10.1159/000525962
Source: Cancer Control - July 11, 2022 Category: Cancer & Oncology Authors: Giuseppe Di Lorenzo Concetta Ingenito Bruno D'Ambrosio Chiara Ranieri Mario Iervolino Ferdinando Primiano Luciana Buonerba Giuseppina Busto Claudia Ferrara Annamaria Libroia Gianluca Ragone Ferdinando De Falco Ferdinando Costabile Pietro Fimiani Francesco Source Type: research